Estrogen therapy breast cancer

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Breast cancer is a malignant tumor that begins and grows in the breast. Malignant tumors can grow and invade nearby tissues or travel to distant organs. This progression is called metastasis.

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High-dose estrogen was generally considered the endocrine therapy of choice for postmenopausal women with breast cancer prior to the introduction of tamoxifen. Subsequently, the use of estrogen was largely abandoned. Recent clinical trial data have shown clinically meaningful efficacy for high-dose estrogen even in patients with extensive prior endocrine therapy.

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Hormones are substances that function as chemical messengers in the body. They affect the actions of cells and tissues at various locations in the body, often reaching their targets through the bloodstream. The hormones estrogen and progesterone are produced by the ovaries in premenopausal women and by some other tissues, including fat and skin, in both premenopausal and postmenopausal women and men.

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By Debora MacKenzie. Hormone replacement therapy may be even more likely to cause breast cancer than we thought. But how much bigger is the risk, and is it so high that no one should take it?

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Hormones like estrogen and progesterone are chemicals produced by glands in the body. Normally, these hormones help regulate body cycles, like menstruation. However, sometimes these same hormones can cause cancer to grow.

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Member contributors included Ruth Farrell, MD. This document reflects emerging clinical and scientific advances as of the date issued and is subject to change. The information should not be construed as dictating an exclusive course of treatment or procedure to be followed.

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Jeffrey D. Blaustein does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment. Republish our articles for free, online or in print, under Creative Commons licence.

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The decline in MHT has been paralleled by a concomitant decrease in breast cancer incidence rates. Following the release of WHI results, there was a sharp decline in breast cancer incidence rates in the U. On July 9,officials from the National Institutes of Health announced that one form of hormone therapy HTPrempro, was found to cause breast cancer in previously healthy women.

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Arch Intern Med. We sought to assess the relationship between longer-term use of unopposed estrogen and the risk of invasive breast cancer over an extended follow-up period. Estrogen use was assessed from self-reported data on biennial questionnaires.

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In the Women's Health Initiative, 8, women took combination hormone replacement therapy estrogen and progestin and were followed for an average of 5. The women were evaluated for high risk by the Gail Model and were not found to be at increased risk of developing breast cancer. They had yearly mammograms and breast exams during their follow-up visits. The number of in situ early stage breast cancers was not affected.

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